Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition.
Identifieur interne : 000296 ( Main/Exploration ); précédent : 000295; suivant : 000297Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition.
Auteurs : Nicholas E. Thomford [Afrique du Sud] ; Kevin Dzobo [Afrique du Sud] ; Denis Chopera [Afrique du Sud] ; Ambroise Wonkam [Afrique du Sud] ; Michelle Skelton [Afrique du Sud] ; Dee Blackhurst [Afrique du Sud] ; Shadreck Chirikure [Afrique du Sud] ; Collet Dandara [Afrique du Sud]Source :
- Pharmaceuticals (Basel, Switzerland) [ 1424-8247 ] ; 2015.
Abstract
The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level.
DOI: 10.3390/ph8030637
PubMed: 26402689
Affiliations:
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This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, the overlap between conventional medicine and herbal medicine is a reality among countries in health systems transition. Patients often simultaneously seek treatment from both conventional and traditional health systems for the same condition. Commonly encountered conditions/diseases include malaria, HIV/AIDS, hypertension, tuberculosis, and bleeding disorders. It is therefore imperative to understand the modes of interaction between different drugs from conventional and traditional health care systems when used in treatment combinations. Both conventional and traditional drug entities are metabolized by the same enzyme systems in the human body, resulting in both pharmacokinetics and pharmacodynamics interactions, whose properties remain unknown/unquantified. Thus, it is important that profiles of interaction between different herbal and conventional medicines be evaluated. This review evaluates herbal and conventional drugs in a few African countries and their potential interaction at the pharmacogenomics level.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Thomford, Nicholas E" sort="Thomford, Nicholas E" uniqKey="Thomford N" first="Nicholas E" last="Thomford">Nicholas E. Thomford</name></noRegion><name sortKey="Blackhurst, Dee" sort="Blackhurst, Dee" uniqKey="Blackhurst D" first="Dee" last="Blackhurst">Dee Blackhurst</name><name sortKey="Chirikure, Shadreck" sort="Chirikure, Shadreck" uniqKey="Chirikure S" first="Shadreck" last="Chirikure">Shadreck Chirikure</name><name sortKey="Chopera, Denis" sort="Chopera, Denis" uniqKey="Chopera D" first="Denis" last="Chopera">Denis Chopera</name><name sortKey="Dandara, Collet" sort="Dandara, Collet" uniqKey="Dandara C" first="Collet" last="Dandara">Collet Dandara</name><name sortKey="Dzobo, Kevin" sort="Dzobo, Kevin" uniqKey="Dzobo K" first="Kevin" last="Dzobo">Kevin Dzobo</name><name sortKey="Skelton, Michelle" sort="Skelton, Michelle" uniqKey="Skelton M" first="Michelle" last="Skelton">Michelle Skelton</name><name sortKey="Wonkam, Ambroise" sort="Wonkam, Ambroise" uniqKey="Wonkam A" first="Ambroise" last="Wonkam">Ambroise Wonkam</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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